Anti-Inhibin α Clone PO12/8

Catalogue No. Target Research Areas Applications Size Price (£)
PO12/8-100UG Inhibin α Endocrinology
Cancer
Fertility
Cell biology
ELISA
IHC
0.1mg 300.00

Description

Higher levels of inhibin α have been associated with a higher risk of cancer progression and recurrence. Clone PO 12/8 is useful in detecting inhibin α levels, especially in prostate cancer cells.

Specifications

Form in stock: IgG, purified – 1.0 mg/mL. Also available as unpurified supernatant.
Host: Mouse
Specificity: Synthetic peptide corresponding to epitope region aa73-96 of the αC region of α subunit of inhibin A. (Robertson D.M. et al.)
Human Histology positive control: Prostate tissue
Fusion partner: Spleen cells from immunised Balb/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
Storage: Store at +4°C or -20°C. Avoid repeated freezing and thawing.
Shelf life: 18 months from date of dispatch.
Regulatory/ Restrictions: For research and commercial purposes.

Applications
Application Suggested Dilution
ELISA Assay dependent
IHC 90 μg/ml3
References
  1. Balanathan, P., Williams, E. D., Wang, H., Pedersen, J. S., Horvath, L. G., Achen, M. G., … Risbridger, G. P. (2009). Elevated level of inhibin-α subunit is pro-tumourigenic and pro-metastatic and associated with extracapsular spread in advanced prostate cancer. British Journal of Cancer, 100(11), 1784–1793.
  2. D.M. Robertson, T. Stephenson, N. Cahir, A. Tsigos, E. Pruysers, P.G. Stanton, N. Groome, P. Thirunavukarasu, Development of an inhibin α subunit ELISA with broad specificity, Molecular and Cellular Endocrinology, Volume 180, Issues 1–2, 30 July 2001, Pages 79-86, ISSN 0303-7207.
  3. G.P. Risbridger, E.M.A. Ball, H. Wang, S.L. Mellor, D.M. Peehl, Re-evaluation of inhibin α subunit as a tumour suppressor in prostate cancer, Molecular and Cellular Endocrinology, Volume 225, Issues 1–2, 15 October 2004, Pages 73-76, ISSN 0303-7207.

Clone PO 12/8 used to stain prostate cancer cells and detect levels of inhibin a by IHC-P

INHα expression in clinical specimens and its association to prostate disease. Immunohistochemical staining of INHα in primary prostate tumours from PCa patients with (A–D) organ-confined (negative) and (E–H) metastatic disease (positive). (Balanathan, P et al.)

Clone PO 12/8 used to stain prostate cancer cells and detect levels of inhibin a by IHC-P

Immunostaining in biopsy specimens from men with prostate cancer in regions of non-malignant (a, c, e) or malignant (b, d, f) tissue… Panels e and f show the up-regulation of inhibin α subunit immunoreactivity in malignant compared to non-malignant regions of tissue using the monoclonal antibody, PO#12. (Risbridger G.P et al.)
Dilution used: 90 μg/ml

Clone PO12/8 Datasheet

PO12/8 Publications

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