Anti-Proteolipid Protein Clone PLPC1

Proteolipid protein (PLP) is the major myelin protein of the CNS and plays an important role in the formation and maintenance of myelin. Mutations in PLP gene can lead to dysmyelinating diseases. Clone PLPC1 is used in the detection of PLP by various analysis methods.

Catalogue No. Target Research Areas Applications Size Price (£)
PLPC1-100UG Proteolipid protein Immunology
Neuroscience
Infectious diseases
Cardiology
FC
WB
IHC
IF
ICC
0.1mg 300.00

Clone PLPC1 used to detect mouse myelin binding via Flow Cytometry

Incubation of mouse myelin with mAb against myelin components. The binding is visualized by incubating the mAb-myelin with fluorescent labelled conjugates. The fluorescence intensity (FL2) of the myelin was measured using FACScan flow Cytometry. The data are presented as the geo-mean of fluorescence of one representative experiment (n=4). (Van der Goesa, et al.)
Dilution used: 75μg/ml

Clone PLPC1 used for the detection of PLP in brain tissue by Western Blot

Human (G-I) brain extracts were analyzed by immunoblotting using antibodies against antigens selected among the monomer and oligomer binding proteins… (Betzer, C et al.)
Dilution used: 1:250

Clone PLPC1 used for the detection of PLP in brain tissue by IHC-P

A) Type-I NL with demyelination of the whole width of the cortex (#) and adjacent WM (*). (B) Type-II intracortical lesion evolving around a vessel. (C) Type-III subpial NL. Demyelination spreads from the pial surface until cortical layer 3. (Yao, B et al.)
Dilution used: 1:1000

Clone PLPC1 used for the detection of PLP in brain tissue by ICC

l: The active lesion edge of the cortical lesions contains numerous macrophages with PLP reactive myelin degradation products… (Höftberger, R et al.)
Dilution used: 1:1000

Clone PLPC1 used for the detection of PLP in brain tissue by IF

Image caption: … PLP (B, D, and F; TRITC) in the ventral cervical spinal cords of me/me (A to D) mice 5 days after inoculation with TMEV… (Massa, P. T et al.)

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