1. Home
  2. Recombinant Proteins and Antibody Research Tools
  3. SARS-CoV-2 Recombinant Proteins
  4. 2019 Coronavirus SARS-CoV-2 Receptor Binding Motif (1 mg)

2019 Coronavirus SARS-CoV-2 Receptor Binding Motif (1 mg)


1 mg

SKU: LT5578

2019 Coronavirus SARS-CoV-2 Receptor Binding Motif is a synthetic peptide part of the receptor-binding domain (RBD). It is a critical determinant of virus-receptor interaction and thus of viral host range and tropism. The RBD also includes important viral-neutralizing epitopes (21–23), and it may be sufficient to raise a protective antibody response in inoculated animals.

A total of nine cysteine residues are found in the RBD, six of which forming three pairs of disulfide bonds. Among these three pairs, two are in the core (Cys336-Cys361 and Cys379-Cys432) to help stabilize the beta sheet structure while the remaining one (Cys480-Cys488) connects loops in the distal end of the RBM.

Studies showed that the sequence of 2019-nCoV coronavirus RBD, including its receptor -binding motif (RBM) that directly contacts ACE2 and uses ACE2 as its receptor with much higher affinity (10-20 times higher!) than SARS.

Modifications: N-Terminal: Biotin Labelling, Disulphide
Bridge: Cys480-Cys488
Formula: C361H528N96O109S3
Molecular weight: 8052.94 g/mol
Regulatory/Restrictions: For Research Use Only.