Bepotastine 5 mg


Histamine receptor antagonist

SKU: BSV-S5940

Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor that is indicated in allergic rhinitis, urticaria, and pruritus associated with skin disease.

Target: histamine 1 (H1) receptor

Chemical name: 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-

Formula: C21H25ClN2O3

Molecular weight: 388.89

Purity: 99.38 %

Solubility: 78 mg/mL (DMSO), 78 mg/mL (ethanol), 78 mg/mL (water)

Size: 5 mg

Storage: 3 years -20°C powder, 2 years -80°C in solvent

Because of a type 1 hypersensitivity reaction cascade that is triggered by antigen exposure, allergic conjunctivitis occurs. Allergen exposure is followed by conjunctival mast cell degranulation and histamine released as a result of the formation of complementary IgE cross-links on the conjunctiva. Due to the release of histamine, symptoms such as itching can be observed. Bepotastine works to relieve itchy eyes by three primary mechanisms of action. It is a non-sedating, selective antagonist of the histamine 1 (H1) receptor, a mast cell stabilizer, and it suppresses the migration of eosinophils into inflamed tissues to prevent tissue damage and worsening of allergic inflammation of the conjunctiva.