Coronavirus SARS-CoV-2 Surface Glycoprotein, 74 amino acids (1 mg)

£1,267.00

1 mg

SKU: LT5587

Receptor-binding motif (RBM) of 2019 Coronavirus SARS-CoV-2 surface glycoprotein. This receptor-binding domain (RBD) a critical determinant of virus-receptor interaction and thus of viral host range and tropism. The RBD also includes important viral-neutralizing epitopes (21–23), and it may be sufficient to raise a protective antibody response in inoculated animals.
A total of nine cysteine residues are found in the RBD, six of which forming three pairs of disulfide bonds. Among these three pairs, two are in the core (Cys336-Cys361 and Cys379-Cys432) to help stabilize the beta sheet structure while the remaining one (Cys480-Cys488) connects loops in the distal end of the RBM.
Studies showed that the sequence of 2019-nCoV coronavirus RBD, including its receptor -binding motif (RBM) that directly contacts ACE2 and uses ACE2 as its receptor with much higher affinity (10-20 times higher!) than SARS.

Peptide sequence: NH2- VIAWNSNNLD SKVGGNYNYL YRLFRKSNLK PFERDISTEI YQAGSTPCNG VEGFNCYFPL QSYGFQPTNG VGYQ -CONH2
Three letter sequence: NH2- Val – Ile – Ala – Trp – Asn – Ser – Asn – Asn – Leu – Asp – Ser – Lys – Val – Gly – Gly – Asn – Tyr – Asn – Tyr – Leu – Tyr – Arg – Leu – Phe – Arg – Lys – Ser – Asn – Leu – Lys – Pro – Phe – Glu – Arg – Asp – Ile – Ser – Thr – Glu – Ile – Tyr – Gln – Ala – Gly – Ser – Thr – Pro – Cys – Asn – Gly – Val – Glu – Gly – Phe – Asn – Cys – Tyr – Phe – Pro – Leu – Gln – Ser – Tyr – Gly – Phe – Gln – Pro – Thr – Asn – Gly – Val – Gly – Tyr – Gln -CONH2
Modifications: Disulphide Bridge: Cys480-Cys488
Purity: >97% by HPLC
Molecular weight: 8410.21 g/mol
Regulatory/Restrictions: For Research Use Only.