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SARS-CoV-2 full-length Trimeric Spike Recombinant Protein P.1 Mutation (Brazil Variant)

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SKU: Brazil Variant

All viruses undergo fast mutations and adept quickly to the countermeasures that the immune systems creates against them. SARS-CoV-2 of the COVID-19 pandemic is no exception here. Spike protein of the mutant strain P.1, also commonly known as the “Brazil Variant”. It is a full-length protein, which is active in its native trimeric form, that is stabilized in LMNG detergent.

SARS-CoV-2 full-length Trimeric Spike Recombinant Protein P.1_Datasheet

Features

WHO ReferenceB.1.128
Alternative NamesSPIKE_SARS2 Spike glycoprotein
UniProt NumberP0DTC2
Protein ClassSingle span transmembrane protein
OrganismSevere acute respiratory syndrome coronavirus (2019-nCoV) (SARS-CoV-2)
Mutation that differ from the "original" SPIKE proteinL18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027l, V1176F
Further Modificationsfurin cleavage site “RRAR” mutated to “GSAG”; KV986PP
C-terminal Rho1D4 tag fused with spacer “GSSG” to protein sequence
Affinity TagC-terminal Rho1D4
Expression HostHek293 Expi cells
Size1286 amino acids (including Rho1D4 tag and linker) 142.11 kDa
Buffer Composition20 mM Hepes pH 7.5; 150 mM NaCl, 0.001% LMNG
FunctionHost cell surface receptor binding; fusion of virus membrane with host endosome membrane
Purity (SDS-PAGE)>98% as determined by SDS-PAGE
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