SARS-CoV-2 Spike Antigen B.1.1.7 (UK Variant)

All viruses undergo fast mutations and adept quickly to the countermeasures that the immune systems creates against them. SARS-CoV-2 of the COVID-19 pandemic is no exception here. During the pandemic multiple mutant strains arose. Spike protein of the mutant strain B.1.1.7, also commonly known as the “UK Variant”. It is a full-length protein, which is active in its native trimeric form, that is stabilized in LMNG detergent.

UK Variant Features

Product Name: SARS-CoV-2 full-length Trimeric Spike Recombinant Antigen (UK Variant)
WHO Label: Alpha
UniProt Number: P0DTC2
Host: HEK293
Mutations that differ from SPIKE Protein: del 69-70, del 144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H
Further Modifications: Furin cleavage site “RRAR” mutated to “GSAG”; K986P V987P
Buffer Composition: 20 mM Hepes pH 7.5; 150 mM NaCl, 0.001% LMNG
Molecular Weight: 142 kDa